Cell Senescence Entries for PINK1
- Cell Types
- Nucleus pulposus
- Cell Lines
- Primary cell
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Stress-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Wang et al. (2019) PINK1 protects against oxidative stress induced senescence of human nucleus pulposus cells via regulating mitophagy. Biochem Biophys Res Commun 504(2)406-414 (PubMed)
PINK1 Gene Information
- HGNC symbol
- PINK1
- Aliases
- BRPK; PARK6
- Common name
- PTEN induced kinase 1
- Entrez Id
- 65018
- Description
- This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008].
PINK1 Ontologies
- Gene Ontology
-
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:16567; protein ubiquitination
GO:6914; autophagy
GO:35556; intracellular signal transduction
GO:50821; protein stabilization
GO:422; autophagy of mitochondrion
GO:42981; regulation of apoptotic process
GO:31396; regulation of protein ubiquitination
GO:1903146; regulation of autophagy of mitochondrion
GO:1903214; regulation of protein targeting to mitochondrion
And 70 more GO terms Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:5783; endoplasmic reticulum
GO:5739; mitochondrion
GO:5743; mitochondrial inner membrane
GO:5741; mitochondrial outer membrane
GO:5829; cytosol
GO:5634; nucleus
GO:48471; perinuclear region of cytoplasm
GO:785; chromatin
And 9 more GO terms Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:31625; ubiquitin protein ligase binding
GO:5515; protein binding
And 9 more GO terms
Homologs of PINK1 in Model Organisms
- Caenorhabditis elegans
- pink-1
- Danio rerio
- pink1
- Drosophila melanogaster
- Pink1
- Mus musculus
- Pink1
- Rattus norvegicus
- Pink1
In other databases
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as Pink1
- CellAge gene expression
- This gene is present as PINK1
External links
- OMIM
- 608309
- Ensembl
- ENSG00000158828
- Entrez Gene
- 65018
- UniGene
- 389171
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- PINK1
- GeneCards
- PINK1