Cell Senescence Entries for PINK1

Cell Types
Nucleus pulposus
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Wang et al. (2019) PINK1 protects against oxidative stress induced senescence of human nucleus pulposus cells via regulating mitophagy. Biochem Biophys Res Commun 504(2)406-414 (PubMed)

PINK1 Gene Information

HGNC symbol
PINK1 
Aliases
BRPK; PARK6 
Common name
PTEN induced kinase 1 
Entrez Id
65018
Description
This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008].

PINK1 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:16567; protein ubiquitination
GO:6914; autophagy
GO:35556; intracellular signal transduction
GO:50821; protein stabilization
GO:422; autophagy of mitochondrion
GO:42981; regulation of apoptotic process
GO:31396; regulation of protein ubiquitination
GO:1903146; regulation of autophagy of mitochondrion
GO:1903214; regulation of protein targeting to mitochondrion
And 70 more GO terms
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:5783; endoplasmic reticulum
GO:5739; mitochondrion
GO:5743; mitochondrial inner membrane
GO:5741; mitochondrial outer membrane
GO:5829; cytosol
GO:5634; nucleus
GO:48471; perinuclear region of cytoplasm
GO:785; chromatin
And 9 more GO terms
Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:31625; ubiquitin protein ligase binding
GO:5515; protein binding
And 9 more GO terms
Show all GO terms

Homologs of PINK1 in Model Organisms

Caenorhabditis elegans
pink-1
Danio rerio
pink1
Drosophila melanogaster
Pink1
Mus musculus
Pink1
Rattus norvegicus
Pink1

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as Pink1
CellAge gene expression
  • This gene is present as PINK1

External links

OMIM
608309
Ensembl
ENSG00000158828
Entrez Gene
65018
UniGene
389171
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PINK1
GeneCards
PINK1