Cell Senescence Entries for PIK3CA
- Cell Types
- Foreskin fibroblast
- Cell Lines
- BJ
- Cancer Cell?
- No
- Method
- Mutation
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Unclear
- Primary Reference
- Astle et al. (2012) AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy. Oncogene 31(15)1949-62 (PubMed)
PIK3CA Gene Information
- HGNC symbol
- PIK3CA
- Aliases
- PI3K
- Common name
- phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
- Entrez Id
- 5290
- Description
- Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22. [provided by RefSeq, Apr 2016].
PIK3CA Ontologies
- Gene Ontology
-
Process: GO:16310; phosphorylation
GO:6468; protein phosphorylation
GO:6629; lipid metabolic process
GO:46854; phosphatidylinositol phosphate biosynthetic process
GO:30168; platelet activation
GO:48015; phosphatidylinositol-mediated signaling
GO:1525; angiogenesis
GO:32147; activation of protein kinase activity
GO:14065; phosphatidylinositol 3-kinase signaling
GO:6909; phagocytosis
GO:16477; cell migration
And 46 more GO terms Cellular component: GO:5737; cytoplasm
GO:5886; plasma membrane
GO:5942; phosphatidylinositol 3-kinase complex
GO:16020; membrane
GO:5829; cytosol
GO:48471; perinuclear region of cytoplasm
GO:5943; phosphatidylinositol 3-kinase complex, class IA
GO:14704; intercalated disc
GO:5944; phosphatidylinositol 3-kinase complex, class IB
GO:30027; lamellipodium
Function: GO:5515; protein binding
GO:166; nucleotide binding
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:46934; phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:52812; phosphatidylinositol-3,4-bisphosphate 5-kinase activity
GO:35004; phosphatidylinositol 3-kinase activity
And 6 more GO terms
Homologs of PIK3CA in Model Organisms
- Danio rerio
- pik3ca
- Drosophila melanogaster
- Pi3K92E
- Mus musculus
- Pik3ca
- Rattus norvegicus
- AABR07037536.1
- Rattus norvegicus
- Pik3ca
- Saccharomyces cerevisiae
- VPS34
In other databases
- GenAge model organism genes
- GenAge human genes
- This gene is present as PIK3CA
- LongevityMap
- This gene is present as PIK3CA
External links
- OMIM
- 171834
- Ensembl
- ENSG00000121879
- Entrez Gene
- 5290
- UniGene
- 715194
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- PIK3CA
- GeneCards
- PIK3CA