Cell Senescence Entries for PIK3C2A
- Cell Types
- Embryonic kidney, Retinal pigment epithelial
- Cell Lines
- HEK293T, HTERT-RPE1
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Unclear
- Primary Reference
- Lahtela et al. (2013) A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3. Cell Cycle 12(4)625-34 (PubMed)
PIK3C2A Gene Information
- HGNC symbol
- PIK3C2A
- Aliases
- PI3K-C2alpha
- Common name
- phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
- Entrez Id
- 5286
- Description
- The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008].
PIK3C2A Ontologies
- Gene Ontology
-
Process: GO:16310; phosphorylation
GO:6629; lipid metabolic process
GO:6887; exocytosis
GO:46854; phosphatidylinositol phosphate biosynthetic process
GO:6661; phosphatidylinositol biosynthetic process
GO:48015; phosphatidylinositol-mediated signaling
GO:6897; endocytosis
GO:16477; cell migration
GO:48268; clathrin coat assembly
GO:14065; phosphatidylinositol 3-kinase signaling
GO:36092; phosphatidylinositol-3-phosphate biosynthetic process
And 8 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5794; Golgi apparatus
GO:31410; cytoplasmic vesicle
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5886; plasma membrane
GO:5802; trans-Golgi network
GO:31982; vesicle
And 4 more GO terms Function: GO:166; nucleotide binding
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:35091; phosphatidylinositol binding
GO:46934; phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:52812; phosphatidylinositol-3,4-bisphosphate 5-kinase activity
GO:35004; phosphatidylinositol 3-kinase activity
GO:35005; 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:16303; 1-phosphatidylinositol-3-kinase activity
GO:52742; phosphatidylinositol kinase activity
And 2 more GO terms
Homologs of PIK3C2A in Model Organisms
- Caenorhabditis elegans
- piki-1
- Danio rerio
- pik3c2a
- Drosophila melanogaster
- Pi3K68D
- Mus musculus
- Pik3c2a
- Rattus norvegicus
- Pik3c2a
- Saccharomyces cerevisiae
- VPS34
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as VPS34
External links
- OMIM
- 603601
- Ensembl
- ENSG00000011405
- Entrez Gene
- 5286
- UniGene
- 736397
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- PIK3C2A
- GeneCards
- PIK3C2A