Cell Senescence Entries for PDPK1

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Ferrand et al. (2016) Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7(11)986-1003 (PubMed)

PDPK1 Gene Information

HGNC symbol
PDPK1 
Aliases
PDK1 
Common name
3-phosphoinositide dependent protein kinase 1 
Entrez Id
5170
Description

PDPK1 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:46777; protein autophosphorylation
GO:35556; intracellular signal transduction
GO:18105; peptidyl-serine phosphorylation
GO:97191; extrinsic apoptotic signaling pathway
GO:45766; positive regulation of angiogenesis
GO:6469; negative regulation of protein kinase activity
GO:30036; actin cytoskeleton organization
GO:30512; negative regulation of transforming growth factor beta receptor signaling pathway
GO:7173; epidermal growth factor receptor signaling pathway
And 21 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5829; cytosol
GO:5886; plasma membrane
GO:5925; focal adhesion
GO:30054; cell junction
GO:42995; cell projection
GO:14069; postsynaptic density
GO:31410; cytoplasmic vesicle
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:4676; 3-phosphoinositide-dependent protein kinase activity
GO:16004; phospholipase activator activity
And 2 more GO terms
Show all GO terms

Homologs of PDPK1 in Model Organisms

Caenorhabditis elegans
pdk-1
Danio rerio
pdpk1a
Danio rerio
pdpk1b
Drosophila melanogaster
Pdk1
Mus musculus
Pdpk1
Rattus norvegicus
Pdpk1
Saccharomyces cerevisiae
PKH2
Saccharomyces cerevisiae
PKH3
Saccharomyces cerevisiae
PKH1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as pdk-1
  • A homolog of this gene for Saccharomyces cerevisiae is present as PKH1
  • A homolog of this gene for Saccharomyces cerevisiae is present as PKH3
  • A homolog of this gene for Saccharomyces cerevisiae is present as PKH2
GenAge human genes
  • This gene is present as PDPK1
GenDR gene manipulations
  • A homolog of this gene for Saccharomyces cerevisiae is present as PKH2
LongevityMap
  • This gene is present as PDPK1

External links

OMIM
605213
Ensembl
ENSG00000140992
Entrez Gene
5170
UniGene
459691
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PDPK1
GeneCards
PDPK1