Cell Senescence Entries for KDM4A
- Cell Types
- Lung cancer
- Cell Lines
- A549
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Unclear
- Primary Reference
- Mallette et al. (2013) JMJD2A promotes cellular transformation by blocking cellular senescence through transcriptional repression of the tumor suppressor CHD5. Cell Rep 2(5)1233-43 (PubMed)
KDM4A Gene Information
- HGNC symbol
- KDM4A
- Aliases
- JHDM3A; JMJD2; JMJD2A; KIAA0677; TDRD14A
- Common name
- lysine demethylase 4A
- Entrez Id
- 9682
- Description
- This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009].
KDM4A Ontologies
- Gene Ontology
-
Process: GO:45892; negative regulation of transcription, DNA-templated
GO:6325; chromatin organization
GO:6338; chromatin remodeling
GO:10507; negative regulation of autophagy
GO:33169; histone H3-K9 demethylation
GO:10629; negative regulation of gene expression
GO:10628; positive regulation of gene expression
GO:14898; cardiac muscle hypertrophy in response to stress
GO:16577; histone demethylation
GO:31667; response to nutrient levels
GO:45666; positive regulation of neuron differentiation
And 5 more GO terms Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:1650; fibrillar center
GO:5721; pericentric heterochromatin
GO:5737; cytoplasm
Show all GO termsFunction: GO:46872; metal ion binding
GO:16491; oxidoreductase activity
GO:8270; zinc ion binding
GO:31625; ubiquitin protein ligase binding
GO:51213; dioxygenase activity
GO:5515; protein binding
GO:35064; methylated histone binding
GO:32452; histone demethylase activity
GO:32454; histone demethylase activity (H3-K9 specific)
GO:51864; histone demethylase activity (H3-K36 specific)
Homologs of KDM4A in Model Organisms
- Caenorhabditis elegans
- jmjd-2
- Danio rerio
- kdm4ab
- Danio rerio
- kdm4aa
- Drosophila melanogaster
- Kdm4A
- Drosophila melanogaster
- Kdm4B
- Mus musculus
- Kdm4a
- Rattus norvegicus
- Kdm4a
- Saccharomyces cerevisiae
- GIS1
- Saccharomyces cerevisiae
- RPH1
In other databases
- GenAge model organism genes
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as GIS1
External links
- OMIM
- 609764
- Ensembl
- ENSG00000066135
- Entrez Gene
- 9682
- UniGene
- 155983
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- KDM4A
- GeneCards
- KDM4A