Cell Senescence Entries for DHX9

Cell Types
Lung fibroblast
Cell Lines
MRC-5
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Lee et al. (2014) Suppression of the DHX9 helicase induces premature senescence in human diploid fibroblasts in a p53-dependent manner. J Biol Chem 289(33)22798-22814 (PubMed)

DHX9 Gene Information

HGNC symbol
DHX9 
Aliases
DDX9; LKP; RHA 
Common name
DExH-box helicase 9 
Entrez Id
1660
Description
This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 11 and 13.[provided by RefSeq, Feb 2010].

DHX9 Ontologies

Gene Ontology
Process: GO:6397; mRNA processing
GO:8380; RNA splicing
GO:51028; mRNA transport
GO:6417; regulation of translation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:6260; DNA replication
GO:2376; immune system process
GO:45087; innate immune response
GO:48511; rhythmic process
GO:31047; gene silencing by RNA
GO:6954; inflammatory response
And 40 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5856; cytoskeleton
GO:1990904; ribonucleoprotein complex
GO:36464; cytoplasmic ribonucleoprotein granule
GO:5815; microtubule organizing center
GO:5813; centrosome
And 11 more GO terms
Function: GO:3676; nucleic acid binding
GO:3723; RNA binding
GO:3725; double-stranded RNA binding
GO:46872; metal ion binding
GO:166; nucleotide binding
GO:5524; ATP binding
GO:3677; DNA binding
GO:16787; hydrolase activity
GO:31490; chromatin DNA binding
GO:5515; protein binding
GO:3724; RNA helicase activity
And 30 more GO terms
Show all GO terms

Homologs of DHX9 in Model Organisms

Caenorhabditis elegans
rha-1
Danio rerio
dhx9
Drosophila melanogaster
mle
Mus musculus
Dhx9
Rattus norvegicus
Dhx9
Saccharomyces cerevisiae
851137

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as mle

External links

OMIM
603115
Ensembl
ENSG00000135829
Entrez Gene
1660
UniGene
191518
1000 Genomes
1000 Genomes
HPRD
GenAtlas
DHX9
GeneCards
DHX9