The CRISPLD2 gene and its putative association with human ageing

Cell Senescence Entries for CRISPLD2

Cell Types: Foreskin fibroblast
Cell Lines: BJ
Cancer Cell?: No
Method: Knockout
Type of senescence: Stress-induced
Senescence Effect: Inhibits
Primary Reference: Liu et al. (2020) A large-scale CRISPR screen and identification of essential genes in cellular senescence bypass. Aging (Albany NY) 11(12)4011-4031 (PubMed)

CRISPLD2 Gene Information

HGNC symbol: CRISPLD2
Aliases: DKFZP434B044; LCRISP2; LGL1
Common name: cysteine rich secretory protein LCCL domain containing 2
Entrez Id: 83716
Description

CRISPLD2 Ontologies

Gene Ontology

Process:

GO:30198; extracellular matrix organization
GO:30324; lung development
GO:60325; face morphogenesis

Cellular component:

GO:5576; extracellular region
GO:5615; extracellular space
GO:31012; extracellular matrix
GO:70062; extracellular exosome
GO:34774; secretory granule lumen
GO:1904813; ficolin-1-rich granule lumen
GO:30133; transport vesicle

Function:

GO:5539; glycosaminoglycan binding
GO:8201; heparin binding

Show all GO terms

Homologs of CRISPLD2 in Model Organisms

Caenorhabditis elegans: scl-1
Caenorhabditis elegans: scl-11
Caenorhabditis elegans: scl-10
Caenorhabditis elegans: scl-9
Caenorhabditis elegans: scl-12
Caenorhabditis elegans: scl-18
Caenorhabditis elegans: scl-20
Caenorhabditis elegans: scl-19
Caenorhabditis elegans: scl-17
Caenorhabditis elegans: scl-21
Caenorhabditis elegans: scl-14
Caenorhabditis elegans: scl-15
Caenorhabditis elegans: scl-13
Caenorhabditis elegans: scl-5
Caenorhabditis elegans: scl-3
Caenorhabditis elegans: scl-2
Caenorhabditis elegans: vap-1
Caenorhabditis elegans: vap-2
Caenorhabditis elegans: scl-8
Caenorhabditis elegans: scl-6
Caenorhabditis elegans: scl-7
Caenorhabditis elegans: scl-23
Danio rerio: CRISPLD2
Mus musculus: Crispld2
Rattus norvegicus: Crispld2

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as scl-8
A homolog of this gene for Caenorhabditis elegans is present as scl-1
A homolog of this gene for Caenorhabditis elegans is present as scl-20

Cell Senescence Entries for CRISPLD2

CRISPLD2 Gene Information

CRISPLD2 Ontologies

Homologs of CRISPLD2 in Model Organisms

In other databases

External links