Cell Senescence Entries for CDKN2A

Cell Types
Lung fibroblast
Cell Lines
Cancer Cell?
Type of senescence
Oncogene-induced, Replicative, Stress-induced
Senescence Effect
Primary Reference
Kato et al. (1998) Features of replicative senescence induced by direct addition of antennapedia-p16INK4A fusion protein to human diploid fibroblasts. FEBS Lett 427(2)203-8 (PubMed)

CDKN2A Gene Information

HGNC symbol
ARF; CDK4I; CDKN2; CMM2; INK4; INK4a; MLM; MTS1; p14; p14ARF; p16; p16INK4a; p19; p19Arf 
Common name
cyclin dependent kinase inhibitor 2A 
Entrez Id
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012].

CDKN2A Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:16310; phosphorylation
GO:45892; negative regulation of transcription, DNA-templated
GO:8285; negative regulation of cell population proliferation
GO:90399; replicative senescence
GO:1953; negative regulation of cell-matrix adhesion
GO:30308; negative regulation of cell growth
GO:32088; negative regulation of NF-kappaB transcription factor activity
GO:51726; regulation of cell cycle
GO:7265; Ras protein signal transduction
GO:90398; cellular senescence
And 36 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:35985; senescence-associated heterochromatin focus
GO:5730; nucleolus
GO:5739; mitochondrion
GO:5654; nucleoplasm
GO:5759; mitochondrial matrix
GO:16604; nuclear body
GO:32991; protein-containing complex
Function: GO:5515; protein binding
GO:3723; RNA binding
GO:16301; kinase activity
GO:19901; protein kinase binding
GO:51059; NF-kappaB binding
GO:4861; cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:3677; DNA binding
GO:19789; SUMO transferase activity
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:2039; p53 binding
GO:97718; disordered domain specific binding
And 4 more GO terms
Show all GO terms

Homologs of CDKN2A in Model Organisms

Danio rerio

In other databases

GenAge human genes
  • This gene is present as CDKN2A
  • This gene is present as CDKN2A
CellAge gene expression
  • This gene is present as CDKN2A

External links

Entrez Gene
1000 Genomes
1000 Genomes