Cell Senescence Entries for CBS
- Cell Types
- Aortic endothelial, Umbilical vein endothelial
- Cell Lines
- HAEC, HUVEC
- Cancer Cell?
- No
- Method
- Knockdown, Overexpression
- Type of senescence
- Replicative
- Senescence Effect
- Inhibits
- Primary Reference
- Albertini et al. (2013) Cystathionine beta synthase modulates senescence of human endothelial cells. Aging (Albany NY) 4(10)664-73 (PubMed)
CBS Gene Information
- HGNC symbol
- CBS
- Aliases
- HIP4
- Common name
- cystathionine beta-synthase
- Entrez Id
- 875
- Description
- The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2016].
CBS Ontologies
- Gene Ontology
-
Process: GO:8152; metabolic process
GO:8652; cellular amino acid biosynthetic process
GO:6535; cysteine biosynthetic process from serine
GO:50667; homocysteine metabolic process
GO:19344; cysteine biosynthetic process
GO:6565; L-serine catabolic process
GO:6563; L-serine metabolic process
GO:19448; L-cysteine catabolic process
GO:70814; hydrogen sulfide biosynthetic process
GO:19343; cysteine biosynthetic process via cystathionine
GO:42262; DNA protection
And 2 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
Function: GO:46872; metal ion binding
GO:31625; ubiquitin protein ligase binding
GO:16829; lyase activity
GO:42803; protein homodimerization activity
GO:3824; catalytic activity
GO:5515; protein binding
GO:19899; enzyme binding
GO:42802; identical protein binding
GO:20037; heme binding
GO:30170; pyridoxal phosphate binding
GO:70026; nitric oxide binding
And 7 more GO terms
Homologs of CBS in Model Organisms
- Caenorhabditis elegans
- F59A7.7
- Caenorhabditis elegans
- cysl-4
- Caenorhabditis elegans
- cysl-3
- Caenorhabditis elegans
- cysl-2
- Caenorhabditis elegans
- cysl-1
- Danio rerio
- cbsb
- Danio rerio
- cbsa
- Drosophila melanogaster
- Cbs
- Mus musculus
- Cbs
- Rattus norvegicus
- Cbs
- Saccharomyces cerevisiae
- CYS4
- Schizosaccharomyces pombe
- cys12
In other databases
- GenAge model organism genes
- GenDR gene manipulations
- A homolog of this gene for Drosophila melanogaster is present as Cbs
- CellAge gene expression
- This gene is present as CBS
External links
- OMIM
- 613381
- Ensembl
- ENSG00000160200
- Entrez Gene
- 875
- UniGene
- 533013
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- CBS
- GeneCards
- CBS