Cell Senescence Entries for AKT1

Cell Types
Aortic endothelial, Dermal microvascular endothelial, Umbilical vein endothelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Skeen et al. (2006) Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner. Cancer Cell 10(4)269-80 (PubMed)

AKT1 Gene Information

HGNC symbol
AKT1 
Aliases
AKT; PKB; PRKBA; RAC; RAC-alpha 
Common name
AKT serine/threonine kinase 1 
Entrez Id
207
Description
This gene encodes one of the three members of the human AKT serine-threonine protein kinase family which are often referred to as protein kinase B alpha, beta, and gamma. These highly similar AKT proteins all have an N-terminal pleckstrin homology domain, a serine/threonine-specific kinase domain and a C-terminal regulatory domain. These proteins are phosphorylated by phosphoinositide 3-kinase (PI3K). AKT/PI3K forms a key component of many signalling pathways that involve the binding of membrane-bound ligands such as receptor tyrosine kinases, G-protein coupled receptors, and integrin-linked kinase. These AKT proteins therefore regulate a wide variety of cellular functions including cell proliferation, survival, metabolism, and angiogenesis in both normal and malignant cells. AKT proteins are recruited to the cell membrane by phosphatidylinositol 3,4,5-trisphosphate (PIP3) after phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) by PI3K. Subsequent phosphorylation of both threonine residue 308 and serine residue 473 is required for full activation of the AKT1 protein encoded by this gene. Phosphorylation of additional residues also occurs, for example, in response to insulin growth factor-1 and epidermal growth factor. Protein phosphatases act as negative regulators of AKT proteins by dephosphorylating AKT or PIP3. The PI3K/AKT signalling pathway is crucial for tumor cell survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating AKT1 which then phosphorylates and inactivates components of the apoptotic machinery. AKT proteins also participate in the mammalian target of rapamycin (mTOR) signalling pathway which controls the assembly of the eukaryotic translation initiation factor 4F (eIF4E) complex and this pathway, in addition to responding to extracellular signals from growth factors and cytokines, is disregulated in many cancers. Mutations in this gene are associated with multiple types of cancer and excessive tissue growth including Proteus syndrome and Cowden syndrome 6, and breast, colorectal, and ovarian cancers. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2020].

AKT1 Ontologies

Gene Ontology
Process: GO:10628; positive regulation of gene expression
GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:43066; negative regulation of apoptotic process
GO:6915; apoptotic process
GO:5975; carbohydrate metabolic process
GO:6417; regulation of translation
GO:7165; signal transduction
GO:30154; cell differentiation
GO:5977; glycogen metabolic process
GO:7399; nervous system development
And 132 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:5886; plasma membrane
GO:5829; cytosol
GO:15630; microtubule cytoskeleton
GO:31982; vesicle
GO:98794; postsynapse
GO:30027; lamellipodium
And 6 more GO terms
Function: GO:5515; protein binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:42803; protein homodimerization activity
GO:42802; identical protein binding
And 9 more GO terms
Show all GO terms

Homologs of AKT1 in Model Organisms

Caenorhabditis elegans
akt-2
Caenorhabditis elegans
akt-1
Danio rerio
AKT1
Drosophila melanogaster
Akt1
Mus musculus
Akt1
Rattus norvegicus
Akt1
Saccharomyces cerevisiae
SCH9
Saccharomyces cerevisiae
YPK1
Saccharomyces cerevisiae
YPK2

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as akt-1
  • A homolog of this gene for Saccharomyces cerevisiae is present as SCH9
  • A homolog of this gene for Drosophila melanogaster is present as Akt1
  • A homolog of this gene for Saccharomyces cerevisiae is present as YPK1
  • A homolog of this gene for Mus musculus is present as Akt1
GenAge human genes
  • This gene is present as AKT1
GenDR gene manipulations
  • A homolog of this gene for Saccharomyces cerevisiae is present as SCH9
LongevityMap
  • This gene is present as AKT1

External links

OMIM
164730
Ensembl
ENSG00000142208
Entrez Gene
207
UniGene
525622
1000 Genomes
1000 Genomes
HPRD
GenAtlas
AKT1
GeneCards
AKT1