The PTGS2 gene and its putative association with human ageing

Cell Types

Foreskin fibroblast

Cell Lines

NHDF

Cancer Cell?

No

Method

Overexpression

Type of senescence

Replicative, Stress-induced

Senescence Effect

Induces

Primary Reference

Cormenier et al. (2018) The ATF6α arm of the Unfolded Protein Response mediates replicative senescence in human fibroblasts through a COX2/prostaglandin E2 intracrine pathway. Mech Ageing Dev 170(2)82-91 (PubMed)

HGNC symbol

PTGS2

Aliases

COX2

Common name

prostaglandin-endoperoxide synthase 2

Entrez Id

5743

Description

Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009].

Gene Ontology

Process:

GO:6629; lipid metabolic process
GO:6631; fatty acid metabolic process
GO:6633; fatty acid biosynthetic process
GO:6954; inflammatory response
GO:8217; regulation of blood pressure
GO:1516; prostaglandin biosynthetic process
GO:6693; prostaglandin metabolic process
GO:98869; cellular oxidant detoxification
GO:6979; response to oxidative stress
GO:19371; cyclooxygenase pathway
GO:90050; positive regulation of cell migration involved in sprouting angiogenesis
GO:50727; regulation of inflammatory response
GO:71456; cellular response to hypoxia
GO:45429; positive regulation of nitric oxide biosynthetic process
GO:10575; positive regulation of vascular endothelial growth factor production
GO:90336; positive regulation of brown fat cell differentiation
GO:31622; positive regulation of fever generation
GO:71636; positive regulation of transforming growth factor beta production
GO:1525; angiogenesis
GO:7566; embryo implantation
GO:7568; aging
GO:7612; learning
GO:7613; memory
GO:8284; positive regulation of cell population proliferation
GO:8285; negative regulation of cell population proliferation
GO:9314; response to radiation
GO:9410; response to xenobiotic stimulus
GO:9750; response to fructose
GO:10033; response to organic substance
GO:10042; response to manganese ion
GO:10226; response to lithium ion
GO:10243; response to organonitrogen compound
GO:10942; positive regulation of cell death
GO:14070; response to organic cyclic compound
GO:19233; sensory perception of pain
GO:30282; bone mineralization
GO:30728; ovulation
GO:31394; positive regulation of prostaglandin biosynthetic process
GO:31915; positive regulation of synaptic plasticity
GO:32227; negative regulation of synaptic transmission, dopaminergic
GO:32355; response to estradiol
GO:32496; response to lipopolysaccharide
GO:33138; positive regulation of peptidyl-serine phosphorylation
GO:33280; response to vitamin D
GO:34097; response to cytokine
GO:34605; cellular response to heat
GO:34612; response to tumor necrosis factor
GO:34644; cellular response to UV
GO:35633; maintenance of blood-brain barrier
GO:42127; regulation of cell population proliferation
GO:42307; positive regulation of protein import into nucleus
GO:42633; hair cycle
GO:43065; positive regulation of apoptotic process
GO:43066; negative regulation of apoptotic process
GO:43154; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:45786; negative regulation of cell cycle
GO:45907; positive regulation of vasoconstriction
GO:45986; negative regulation of smooth muscle contraction
GO:45987; positive regulation of smooth muscle contraction
GO:46697; decidualization
GO:48661; positive regulation of smooth muscle cell proliferation
GO:50873; brown fat cell differentiation
GO:51384; response to glucocorticoid
GO:51926; negative regulation of calcium ion transport
GO:51968; positive regulation of synaptic transmission, glutamatergic
GO:70542; response to fatty acid
GO:71260; cellular response to mechanical stimulus
GO:71284; cellular response to lead ion
GO:71318; cellular response to ATP
GO:71471; cellular response to non-ionic osmotic stress
GO:71498; cellular response to fluid shear stress
GO:90271; positive regulation of fibroblast growth factor production
GO:90362; positive regulation of platelet-derived growth factor production
GO:150077; regulation of neuroinflammatory response
GO:1902219; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
GO:1990776; response to angiotensin

Cellular component:

GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:43231; intracellular membrane-bounded organelle
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5637; nuclear inner membrane
GO:5640; nuclear outer membrane
GO:43005; neuron projection
GO:5788; endoplasmic reticulum lumen
GO:5901; caveola
GO:32991; protein-containing complex

Function:

GO:46872; metal ion binding
GO:16491; oxidoreductase activity
GO:51213; dioxygenase activity
GO:5515; protein binding
GO:20037; heme binding
GO:19899; enzyme binding
GO:4601; peroxidase activity
GO:4666; prostaglandin-endoperoxide synthase activity
GO:16702; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:42803; protein homodimerization activity

Hide GO terms

Danio rerio

Danio rerio

Mus musculus

Rattus norvegicus

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