The PDGFB gene and its putative association with human ageing

Cell Types

Dermal fibroblast

Cell Lines

Primary cell

Cancer Cell?

No

Method

Overexpression

Type of senescence

Oncogene-induced

Senescence Effect

Induces

Primary Reference

Vindrieux et al. (2013) Platelet-derived growth factor B induces senescence and transformation in normal human fibroblasts. Aging (Albany NY) 5(7)531-8 (PubMed)

HGNC symbol

PDGFB

Aliases

SIS; SSV

Common name

platelet derived growth factor subunit B

Entrez Id

5155

Description

This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].

Gene Ontology

Process:

GO:10628; positive regulation of gene expression
GO:1904707; positive regulation of vascular associated smooth muscle cell proliferation
GO:45892; negative regulation of transcription, DNA-templated
GO:7165; signal transduction
GO:45893; positive regulation of transcription, DNA-templated
GO:6468; protein phosphorylation
GO:18105; peptidyl-serine phosphorylation
GO:51781; positive regulation of cell division
GO:8284; positive regulation of cell population proliferation
GO:7507; heart development
GO:72593; reactive oxygen species metabolic process
GO:30335; positive regulation of cell migration
GO:43410; positive regulation of MAPK cascade
GO:61098; positive regulation of protein tyrosine kinase activity
GO:2000379; positive regulation of reactive oxygen species metabolic process
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:14068; positive regulation of phosphatidylinositol 3-kinase signaling
GO:50731; positive regulation of peptidyl-tyrosine phosphorylation
GO:1938; positive regulation of endothelial cell proliferation
GO:43406; positive regulation of MAP kinase activity
GO:31954; positive regulation of protein autophosphorylation
GO:50921; positive regulation of chemotaxis
GO:60326; cell chemotaxis
GO:1902894; negative regulation of pri-miRNA transcription by RNA polymerase II
GO:32091; negative regulation of protein binding
GO:32148; activation of protein kinase B activity
GO:10629; negative regulation of gene expression
GO:1902895; positive regulation of pri-miRNA transcription by RNA polymerase II
GO:14911; positive regulation of smooth muscle cell migration
GO:48008; platelet-derived growth factor receptor signaling pathway
GO:2548; monocyte chemotaxis
GO:45840; positive regulation of mitotic nuclear division
GO:48146; positive regulation of fibroblast proliferation
GO:50918; positive chemotaxis
GO:90280; positive regulation of calcium ion import
GO:43536; positive regulation of blood vessel endothelial cell migration
GO:71363; cellular response to growth factor stimulus
GO:9611; response to wounding
GO:10811; positive regulation of cell-substrate adhesion
GO:32147; activation of protein kinase activity
GO:45737; positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:70528; protein kinase C signaling
GO:1905064; negative regulation of vascular associated smooth muscle cell differentiation
GO:18108; peptidyl-tyrosine phosphorylation
GO:10544; negative regulation of platelet activation
GO:2000573; positive regulation of DNA biosynthetic process
GO:1892; embryonic placenta development
GO:3104; positive regulation of glomerular filtration
GO:10512; negative regulation of phosphatidylinositol biosynthetic process
GO:35655; interleukin-18-mediated signaling pathway
GO:35793; positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:36120; cellular response to platelet-derived growth factor stimulus
GO:38001; paracrine signaling
GO:43552; positive regulation of phosphatidylinositol 3-kinase activity
GO:48661; positive regulation of smooth muscle cell proliferation
GO:71506; cellular response to mycophenolic acid
GO:72126; positive regulation of glomerular mesangial cell proliferation
GO:72255; metanephric glomerular mesangial cell development
GO:1900127; positive regulation of hyaluronan biosynthetic process
GO:1904754; positive regulation of vascular associated smooth muscle cell migration
GO:1905176; positive regulation of vascular associated smooth muscle cell dedifferentiation
GO:2000591; positive regulation of metanephric mesenchymal cell migration

Cellular component:

GO:5737; cytoplasm
GO:16020; membrane
GO:5576; extracellular region
GO:16323; basolateral plasma membrane
GO:5615; extracellular space
GO:62023; collagen-containing extracellular matrix
GO:9986; cell surface
GO:139; Golgi membrane
GO:5788; endoplasmic reticulum lumen
GO:31093; platelet alpha granule lumen
GO:5796; Golgi lumen
GO:1990265; platelet-derived growth factor complex

Function:

GO:5515; protein binding
GO:8083; growth factor activity
GO:48018; receptor ligand activity
GO:42802; identical protein binding
GO:42803; protein homodimerization activity
GO:46982; protein heterodimerization activity
GO:5161; platelet-derived growth factor receptor binding
GO:5518; collagen binding
GO:16176; superoxide-generating NADPH oxidase activator activity
GO:42056; chemoattractant activity
GO:48407; platelet-derived growth factor binding
GO:70851; growth factor receptor binding

Hide GO terms

Danio rerio

Danio rerio

Mus musculus

Rattus norvegicus

GenAge human genes