Cell Senescence Entries for SIRT7
- Cell Types
- Breast cancer
- Cell Lines
- MCF-7
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Stress-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Aljada et al. (2015) Modulation of insulin/IGFs pathways by sirtuin-7 inhibition in drug-induced chemoreistance. Diagn Pathol 9(2)94 (PubMed)
SIRT7 Gene Information
- HGNC symbol
- SIRT7
- Aliases
- Common name
- sirtuin 7
- Entrez Id
- 51547
- Description
- This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008].
SIRT7 Ontologies
- Gene Ontology
-
Process: GO:6325; chromatin organization
GO:6476; protein deacetylation
GO:61699; peptidyl-lysine deglutarylation
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:45944; positive regulation of transcription by RNA polymerase II
GO:122; negative regulation of transcription by RNA polymerase II
GO:7129; homologous chromosome pairing at meiosis
GO:10529; negative regulation of transposition
GO:10821; regulation of mitochondrion organization
GO:31397; negative regulation of protein ubiquitination
And 18 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16607; nuclear speck
GO:5654; nucleoplasm
GO:785; chromatin
GO:5694; chromosome
GO:5730; nucleolus
GO:35861; site of double-strand break
GO:5731; nucleolus organizer region
Show all GO termsFunction: GO:46872; metal ion binding
GO:16740; transferase activity
GO:70403; NAD+ binding
GO:34979; NAD-dependent protein deacetylase activity
GO:36055; protein-succinyllysine desuccinylase activity
GO:61697; protein-glutaryllysine deglutarylase activity
GO:5515; protein binding
GO:3714; transcription corepressor activity
GO:3682; chromatin binding
GO:19213; deacetylase activity
GO:4407; histone deacetylase activity
And 3 more GO terms
Homologs of SIRT7 in Model Organisms
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Sirt7
- GenAge human genes
- This gene is present as SIRT7
External links
- OMIM
- 606212
- Ensembl
- ENSG00000187531
- Entrez Gene
- 51547
- UniGene
- 514636
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- SIRT7
- GeneCards
- SIRT7